Peyronie’s Disease

Symptoms of Peyronie’s Disease


Peyronie’s disease – deformity of the penis during erection. The main cause of the disease is the occurrence of a disease process in the albumin and septum of the cavernous bodies of the penis. The etiology of this process has not yet been identified.

Symptoms of Peyronie’s Disease

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There are only three main signs of the disease:

  • Pain in the penis, both at rest and during erection, is the primary symptom of Peyronie’s disease.
  • Plaque formation on the penis

Fibrous plaques are located on the upper (dorsal) surface of the penis. Have the form of dense knots, strands and plates. Plaques are sharply limited, painless. The size of the plaques is 0.5-1.5 cm, the thickness is 2-5 mm. The plaques are localized at different depths, the skin beneath them is mobile and not changed. Most characteristic is their occurrence at the root of the penis, sometimes in the central part, less often at the head.

  • The manifestations of Peyronie’s disease is a curvature of the penis, making it difficult or even impossible to have sexual intercourse.

Peyronie’s disease should be distinguished from cavernitis, periurethritis, post-traumatic deformity of the penis.


Peyronie’s disease can be treated both conservatively and promptly.

In conservative therapy, complex treatment is most effective:

  • taking glucocorticosteroids (cortisone and its derivatives)
  • intake of vitamin E in large doses – daily 200-400 mg for 6-9 months.

The use of cortisone (by injection, or by mouth) reduces the inflammatory processes associated with reactions in the cells.

Also according to some data, the use of enzyme preparations, for example lidases, and biogenic stimulants is not without efficiency.

Physiotherapy is used in a complex manner: diametry, electrophoresis , dyadic currents. 

More recently, ultrasound therapy has been used to treat Peyronie’s disease. Sessions of 5-7 minutes must be performed every other day. The course of treatment is 20-25 sessions.

The use of radiotherapy has shown low efficacy and the risk of complications.


The main indication for surgery for Peyronie’s disease is a genital warp that makes sexual intercourse difficult. Also, the operation can be performed with severe pain or with the ineffectiveness of complex treatment for a long time.

The condition for the operation is a relatively shallow location of the plaques, as well as their sufficient mobility.

Without treatment, Peyronie’s disease almost never passes, since plaques tend to increase in size and quantity.

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